Gut bacteria may influence how well immunotherapy works
If you are a regular reader of nutrition news, you have likely heard of the “microbiome.” This is the community of bacteria that live on and in us, many of which are located in our digestive tracts. These bacteria perform many functions in our body – they help us absorb and produce nutrients and can also help to protect us from harmful bacteria.
Researchers are now beginning to understand that these bacteria may also be involved in how the immune system responds to cancer, and they may even influence whether a form of cancer treatment known as immunotherapy is successful.
Adoptive T cell transfer (ACT) is one form of immunotherapy in which immune cells from a person with cancer are isolated and grown to very large numbers in the lab to be re-injected into the person they came from.
Researchers from Pennsylvania recently published a study suggesting that the make-up of an individual’s microbiome can change how the body responds to ACT. This discovery may impact how the therapy is delivered, in order to make it more effective.